Enzyme Induction by Drugs
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چکیده
منابع مشابه
Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs.
One of the major differences between the older antiepileptic drugs (AEDs) and the newer AEDs is the potential of the older AEDs for significant interactions with other medications. Many of the drug-drug interactions involving the older AEDs are reciprocal, i.e., both drugs affect each other. In contrast, the newer AEDs have either no or limited drug interaction potential. Despite our extensive ...
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Bock, K. W., Bock-Hennig, B. S., Lilienblum, W. & Volp, R. (1981) Chem.-Biol. Interact. 36, 167-177 Bock, K. W., Lilienblum, W., Pfeil, H. & Eriksson, L. C. (1982) Cancer Res. 42, 3747-3752 Bock, K. W., Burchell, B., Dutton, G. J., Hanninen, O., Mulder, G. J., Owens, I. S., Siest, G. & Tephly, T. R. (1983) Biochem. Pharmacol. 32, 953-955 Bock, K. W., Bock-Hennig, B. S., Fischer, G., Lilienblum,...
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Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal fluctuations, dietary constituents, infections ass...
متن کاملEnzyme induction and inhibition.
The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range of drugs may produce clinically significan...
متن کاملThe Effect of Enzyme Induction and Enzyme Inhibition on the Toxicity and Efficacy of the Prescribed Drugs- a Review
The development of the novel therapeutic agents or drugs will be widely affected by Parameters related to the chemistry (structure activity relationship), Pharmacology (mechanism of action of the drug) and the Pharmacokinetic profile of the drug (metabolism characteristics) will play an important role. Before a drug is newly launched in the market various pre clinical studies has to be undertak...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 1978
ISSN: 0004-5632,1758-1001
DOI: 10.1177/000456327801500115